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The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues

Katrin Manda, Stephan Kriesen, Guido Hildebrandt

Med Oncol. 2020; 37(12): 115. Published online 2020 Nov 18. doi: 10.1007/s12032-020-01437-y

PMCID:: PMC7671986

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Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

Jason D Plummer, Spike DL Postnikoff, Jessica K Tyler, Jay E Johnson

eLife. 2021; 10: e62483. Published online 2021 Mar 30. doi: 10.7554/eLife.62483

PMCID:: PMC8009673

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Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro

Le Yang, Yong-Song Cai, Ke Xu, Jia-Lin Zhu, Yuan-Bo Li, Xiao-Qing Wu, Jian Sun, She-Min Lu, Peng Xu

Mol Med Rep. 2018 May; 17(5): 6560–6568. Published online 2018 Mar 6. doi: 10.3892/mmr.2018.8679

PMCID:: PMC5928638

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Inhibition and Removal of Mature Mixed-Bacteria Biofilms on Voice Prostheses by Sodium Selenite

Yongli Zhang, Yanyan Niu, Hong Huo, Jian Wang, Xiaofeng Jin, Hua Yang

Infect Drug Resist. 2022; 15: 7799–7810. Published online 2022 Dec 29. doi: 10.2147/IDR.S393434

Correction in:: Infect Drug Resist. 2023; 16: 809–810.

PMCID:: PMC9807126

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Sodium Selenite Enhances Antibiotics Sensitivity of Pseudomonas aeruginosa and Deceases Its Pathogenicity by Inducing Oxidative Stress and Inhibiting Quorum Sensing System

Weina Kong, Qianqian Tian, Qiaoli Yang, Yu Liu, Gongting Wang, Yanjun Cao, Liping Wang, Sizhe Xia, Yanmei Sun, Cheng Zhao, Shiwei Wang

Antioxidants (Basel) 2021 Dec; 10(12): 1873. Published online 2021 Nov 24. doi: 10.3390/antiox10121873

PMCID:: PMC8698442

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Regulatory effect of chrysin on expression of lenticular calcium transporters, calpains, and apoptotic-cascade components in selenite-induced cataract

Mahalingam Sundararajan, Philip A. Thomas, P. Archana Teresa, Muniyandi Anbukkarasi, Pitchairaj Geraldine

Mol Vis. 2016; 22: 401–423. Published online 2016 Apr 30.

PMCID:: PMC4851856

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Effects of sodium selenite, cysteamine, bacterially synthesized Se-NPs, and cysteamine loaded on Se-NPs on ram sperm cryopreservation

Tannaz Salimi, Hadi Hajarian, Hamed Karamishabankareh, Leila Soltani

Sci Rep. 2024; 14: 852. Published online 2024 Jan 9. doi: 10.1038/s41598-023-50221-1

PMCID:: PMC10774310

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The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study

Kevin Doello, Cristina Mesas, Francisco Quiñonero, Gloria Perazzoli, Laura Cabeza, Jose Prados, Consolacion Melguizo, Raul Ortiz

Cancers (Basel) 2021 Jul; 13(13): 3169. Published online 2021 Jun 25. doi: 10.3390/cancers13133169

PMCID:: PMC8268835

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The Effect of Methylselenocysteine and Sodium Selenite Treatment on microRNA Expression in Liver Cancer Cell Lines

Gábor Lendvai, Tímea Szekerczés, Endre Kontsek, Arun Selvam, Attila Szakos, Zsuzsa Schaff, Mikael Björnstedt, András Kiss

Pathol Oncol Res. 2020; 26(4): 2669–2681. Published online 2020 Jul 12. doi: 10.1007/s12253-020-00870-8

PMCID:: PMC7471166

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Sodium Selenite Acts as an Otoprotectant against Neomycin-Induced Hair Cell Damage in a Zebrafish Model

Jiwon Chang, June Choi, Yoon Chan Rah, Myung Hoon Yoo, Kyoung Ho Oh, Gi Jung Im, Seung Hoon Lee, Soon Young Kwon, Hae-Chul Park, Sung Won Chae, Hak Hyun Jung

PLoS One. 2016; 11(3): e0151557. Published online 2016 Mar 14. doi: 10.1371/journal.pone.0151557

PMCID:: PMC4790947

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Oral intake of α-glucosyl-hesperidin ameliorates selenite-induced cataract formation

Yosuke Nakazawa, Miki Aoki, Sho Ishiwa, Naoki Morishita, Shin Endo, Noriaki Nagai, Naoki Yamamoto, Megumi Funakoshi-Tago, Hiroomi Tamura

Mol Med Rep. 2020 Mar; 21(3): 1258–1266. Published online 2020 Jan 14. doi: 10.3892/mmr.2020.10941

PMCID:: PMC7003023

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Sodium selenite preserves rBM-MSCs’ stemness, differentiation potential, and immunophenotype and protects them against oxidative stress via activation of the Nrf2 signaling pathway

Bahareh Rahimi, Mohammad Panahi, Hajie Lotfi, Mostafa Khalili, Astireh Salehi, Neda Saraygord-Afshari, Effat Alizadeh

BMC Complement Med Ther. 2023; 23: 131. Published online 2023 Apr 25. doi: 10.1186/s12906-023-03952-7

PMCID:: PMC10127330

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Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice

Xinghua Wang, Yukun Yang, Hening Zhang, Ju Liu

Biomed Res Int. 2017; 2017: 3980972. Published online 2017 Oct 30. doi: 10.1155/2017/3980972

PMCID:: PMC5682906

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Sodium Selenite Promotes Osteoblast Differentiation via The WNT/ß-Catenin Signaling Pathway

Ashish Ranjan Sharma, Garima Sharma, Yeon-Hee Lee, Chiranjib Chakraborty, Sang-Soo Lee, Eun-Min Seo

Cell J. 2022 Jun; 24(6): 309–315. Published online 2022 Jun 29. doi: 10.22074/cellj.2022.8314

PMCID:: PMC9315210

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Sodium Selenite Enhanced the Anti-proliferative Effect of MEK-ERK Inhibitor in Thyroid Cancer Cells

BIN JONG KIM, YEOL EUN YANG, JOOHYUN WOO, HYUNGJU KWON, WOOSUNG LIM, BYUNG-IN MOON

In Vivo. 2020 Jan-Feb; 34(1): 185–190. Published online 2020 Jan 3. doi: 10.21873/invivo.11760

PMCID:: PMC6984107

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Development of Formulation Methods and Physical Characterization of Injectable Sodium Selenite Nanoparticles for the Delivery of Sorafenib tosylate

Sivakumar S. Moni, Mohammad F. Alam, Mohammed M. Safhi, Muhammad H. Sultan, Hafiz A. Makeen, Mohamed E. Elmobark

Curr Pharm Biotechnol. 2020 Jul; 21(8): 659–666. Published online 2020 Jul. doi: 10.2174/1389201021666191230124041

PMCID:: PMC7509770

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Sodium selenite supplementation does not fully restore oxidative stress-induced deiodinase dysfunction: Implications for the nonthyroidal illness syndrome

Simone Magagnin Wajner, Helena Cecin Rohenkohl, Tulio Serrano, Ana Luiza Maia

Redox Biol. 2015 Dec; 6: 436–445. Published online 2015 Sep 9. doi: 10.1016/j.redox.2015.09.002

PMCID:: PMC4588414

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Select item 656619518.

Sodium Selenite Alleviates Breast Cancer-Related Lymphedema Independent of Antioxidant Defense System

Hye Won Han, Eun Joo Yang, Seung-Min Lee

Nutrients. 2019 May; 11(5): 1021. Published online 2019 May 7. doi: 10.3390/nu11051021

PMCID:: PMC6566195

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Select item 858425119.

Antitumor Effects of Selenium

Seung Jo Kim, Min Chul Choi, Jong Min Park, An Sik Chung

Int J Mol Sci. 2021 Nov; 22(21): 11844. Published online 2021 Oct 31. doi: 10.3390/ijms222111844

PMCID:: PMC8584251

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Select item 931800220.

Combination of Lanosterol and Nilvadipine Nanosuspensions Rescues Lens Opacification in Selenite-Induced Cataractic Rats

Saori Deguchi, Reita Kadowaki, Hiroko Otake, Atsushi Taga, Yosuke Nakazawa, Manju Misra, Naoki Yamamoto, Hiroshi Sasaki, Noriaki Nagai

Pharmaceutics. 2022 Jul; 14(7): 1520. Published online 2022 Jul 21. doi: 10.3390/pharmaceutics14071520

PMCID:: PMC9318002

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Figure 1

Evaluation of bacterial survival with antibiotics and sodium selenite treatment for various periods. (A) The survival rate of PAO1 treated with sodium selenite, gentamicin, or the combination of the two compounds. (B) The survival rate of PAO1 treated with sodium selenite, tobramycin, or the combination of the two compounds. (C) The survival rate of PAO1 treated with sodium selenite, tetracycline, and the combination of the two compounds. (D) The survival rate of PAO1 treated with sodium selenite, ciprofloxacin, or the combination of the two compounds. (E) The survival rate of PAO1 treated with sodium selenite, ampicillin, or the combination of the two compounds. (F) The survival rate of PAO1 treated with sodium selenite, H₂O₂, or a combination of the two compounds.

Sodium Selenite Enhances Antibiotics Sensitivity of Pseudomonas aeruginosa and Deceases Its Pathogenicity by Inducing Oxidative Stress and Inhibiting Quorum Sensing System

Antioxidants (Basel). 2021 Dec;10(12):1873.
Figure 10Micrographs of samples from patients with hereditary hemochromatosis with added sodium selenite; A) Whole blood with added 10 mM sodium selenite (H63D/wild type); B) Whole blood, with added thrombin and 10 mM sodium selenite (H63D/wild type); C) Platelet rich plasma smear, with added thrombin and 10 mM sodium selenite (H63D/wild type); D) Whole blood with added 0.5 mM sodium selenite (H63D/wild type); E) Whole blood, with added thrombin and 0.5 mM sodium selenite (H63D/wild type); F) Platelet rich plasma smear, with added thrombin and 0.5 mM sodium selenite (H63D/wild type); G) Light microscopy of whole blood with 0.5 mM sodium selenite (C282Y/wild type).

All SEM micrographs scales = 1 µm; light microscopy micrograph scale = 10 µm.

Profound Morphological Changes in the Erythrocytes and Fibrin Networks of Patients with Hemochromatosis or with Hyperferritinemia, and Their Normalization by Iron Chelators and Other Agents

PLoS One. 2014;9(1):e85271.
Figure 1

Effect of sodium selenite on pancreatic cancer cells. (A) Cell viability graphs and IC50 values of sodium selenite and GMZ in PANC-1 and Pan02 cells. Cells were exposed to sodium selenite and GMZ at different doses for 72 h. (B) Morphological changes in PANC-1 and Pan02 cells after exposure to sodium selenite (magnification 10×; detail magnification 15×). Hoestch staining showed nuclear fragmentations (arrows) indicating the presence of apoptotic bodies (apoptotic-like cell death). (C) Combination index (CI) of sodium selenite and GMZ in PANC-1 and Pan02 cells (CI > 1, antagonism; CI < 1, synergism). GMZ (gemcitabine); SEL (sodium selenite).

The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study

Cancers (Basel). 2021 Jul;13(13):3169.
Figure 4Viability after sodium selenite and MEK-ERK inhibitor (U0126) treatment. Thyroid cells were treated with 0.01% ethanol (CTL), 1 μM, 5 μM sodium selenite, or 1 μM U0126 with 5 μM sodium selenite for 72 h. Viable cells were counted in a Neubauer chamber. Results are presented as mean±S.E.M. The results are representative of four independent cultures performed in quadruplet. ***represent a significant effect of U0126 with 5 μM sodium selenite as compared to 5 μM sodium selenite only at p<0.001.

Sodium Selenite Enhanced the Anti-proliferative Effect of MEK-ERK Inhibitor in Thyroid Cancer Cells

In Vivo. 2020 Jan-Feb;34(1):185-190.